1993年毕业于华中科技大学临床医学德语班，1993-2001年5月暨南大学bv伟德源自英国始于1946第三附属医院神经外科主治医师、暨南大学bv伟德源自英国始于1946病理学硕士；2001年6月-2003年6月德国乌尔姆大学bv伟德源自英国始于1946博士研究生（零分答辩）；2003年-2006年德国乌尔姆大学医学博士后；2007-2009年德国慕尼黑大学bv伟德源自英国始于1946博士后研究员；2009年7月至今bv伟德源自英国始于1946，教授、博导。

1.     Wei J, Blum S, Unger M, Jarmy G, Lamparter M, Geishauser A, Vlastos GA, Chan G, Fischer KD, Rattat D, Debatin KM, Hatzopoulos AK*, Beltinger C*.Murine embryonic endothelial progenitor cells (eEPCs) armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Cancer Cell, 2004 May;5(5):477-88.

2.     Wei J, Jarmy G, Genuneit J, Debatin KM, Beltinger C*. Human blood late outgrowth endothelial cells for gene therapy of cancer: determinants of efficacy.  Gene Therapy, 2007 Feb;14(4):344-56.

3.     Wei J, Wahl J, Nakamura T, Stiller D, Mertens T, Debatin KM, Beltinger C*.Targeted release of oncolytic measles virus by blood outgrowth endothelial cells in situ inhibits orthtopic gliomas. Gene Therapy, 2007 Nov;14(22):1573-86.

4.     Ellermeier J#, Wei J#, Duewell P#, Hoves S, Stieg M, Adunka T, Noerenberg D, Anders H, Mayr D, Poeck H, Hartmann G, Endres S, Schnurr M*. Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer. Cancer Research. 2013 Mar 15;73(6):1709-20.

5.     Gang Meng, Mao Xia, Chun Xu, Dongmei Yuan, Max Schnurr*, Jiwu Wei*. Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation. Int J Cancer. 2014 Apr 15;134(8): 1958-71.

6.     Mao Xia, Patrick Gonzalez, Chunyan Li, Gang Meng, Aiqin Jiang, Hongwei Wang, Qian Gao, Klaus-Michael Debatin, Christian Beltinger, Jiwu Wei*. Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. Journal of Virology 2014 May;88(9): 5152-64.

7.     Yuan D, Xia M, Meng G, Xu C, Song Y*, Wei J*.Anti-angiogenic efficacy of 5'-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs. Oncotarget. 2015 Oct 6;6(30):29664-74.

8.     Klionsky DJ*, Abdelmohsen K, Abe A et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.

9.     Chen A, Zhang Y, Meng G, Jiang D, Zhang H, Zheng M, Xia M, Jiang A, Wu J*, Beltinger C, Wei J*.Oncolytic measles virus enhances antitumour responses of adoptive CD8⁺NKG2D⁺ cells in hepatocellular carcinoma treatment. Scientific Reports. 2017 Jul 12;7(1):5170. doi: 10.1038/s41598-017-05500-z.

10.  Zhang Y, Zhang H, Wei M, Mou T, Shi T, Ma Y, Cai X, Li Y, Dong J*, Wei J*.Recombinant Adenovirus Expressing a Soluble Fusion Protein PD-1/CD137L Subverts the Suppression of CD8+ T Cells in HCC. Molecular Therapy. 2019 Aug 5. pii: S1525-0016(19)30358-2. doi: 10.1016/j.ymthe.2019.07.019.

11.  Xia M, Luo D, Dong J, Zheng M, Meng G, Wu J*, Wei J*.Graphene oxide arms oncolytic measles virus for improved effectiveness of cancer therapy. J Exp Clin Cancer Res. 2019 Sep 18;38(1):408. doi: 10.1186/s13046-019-1410-x.

12.  Meng G, Li B, Chen A, Zheng M, Xu T, Zhang H, Dong J, Wu J, Yu D, Wei J*. Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma. Br J Cancer. 2020 Jan;122(1):111-120. doi: 10.1038/s41416-019-0639-7.

13.  Zuo S, Wei M, He B, Chen A, Wang S, Kong L, Zhang Y, Meng G, Xu T, Wu J, Yang F, Zhang H, Wang S, Guo C, Wu J, Dong J, Wei J*. Enhanced antitumor efficacy of a novel oncolytic vaccinia virus encoding a fully monoclonal antibody against T-cell immunoglobulin and ITIM domain (TIGIT). EBioMedicine. 2021 Feb 10;64:103240. doi: 10.1016/j.ebiom.2021.103240.

14.  Zuo S, Wei M, Xu T, Kong L, He B, Wang S, Wang S, Wu J, Dong J, Wei J*. An engineered oncolytic vaccinia virus encoding a single-chain variable f ragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade. J Immunother Cancer. 2021 Dec;9(12):e002843. doi: 10.1136/jitc-2021-002843.

15.  Wang S, Yan W, Kong L, Zuo S, Wu J, Zhu C, Huang H, He B, Dong J, Wei J*. Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma. Nat Commununications. 2023 Jul 20;14(1):4367. doi: 10.1038/s41467-023-39683-z.

16.  Wang S, Li Y, Xu C, Dong J, Wei J*. An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy. J Immunother Cancer. 2024 Mar 7;12(3):e008431. doi: 10.1136/jitc-2023-008431.

17.  Dong J, Kong L, Wang S, Xia M, Zhang Y, Wu J, Yang F, Zuo S, Wei J*. Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice. J Exp Clin Cancer Res. 2024 Apr 3;43(1):102. doi: 10.1186/s13046-024-03011-0.

18.  Zhang Y, He B, Zou P, Wu M, Wei M, Xu C, Dong J, Wei J*. Targeted release of a bispecific fusion protein SIRPα/Siglec-10 by oncolytic adenovirus reinvigorates tumor-associated macrophages to improve therapeutic outcomes in solid tumors. J Immunother Cancer. 2025 Apr 1;13(4):e010767. doi: 10.1136/jitc-2024-010767.

19.  Kang X, Qian P, Han Y, Wu M, Li Y, Xu C, Wei J*. A Bispecific Antibody Targeting PD-L1/TNFR2 Increases Tumor Targeting and Enhances Antitumor Efficacy in Colorectal Cancer. J Immunother Cancer. 2025 Nov 13;13(11):e013001. doi: 10.1136/ jitc-2025-013001.

20.  Kang X, Li Y, Han Y, Wu M, Qian P, Dong J, Wei J*. Dual blockade of TNFR2 and CD47 reshape tumor immune microenvironment and improve antitumor effects in colorectal cancer. Mol Ther. 2025 Sep 3;33(9):4600-4617. doi: 10.1016/j.ymthe.2025. 05.032.

21.  Kang X, Han Y, Wu M, Li Y, Qian P, Xu C, Zou Z, Dong J, Wei J*. In situ blockade of TNF-TNFR2 axis via oncolytic adenovirus improves antitumor efficacy in solid tumors. Mol Ther. 2025 Feb 5;33(2):670-687. doi: 10.1016/j.ymthe.2024.12.011.

22.  Wu J, Qian P, Han Y, Xu C, Xia M, Zhan P, Wei J*, Dong J. GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8+ T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer. Cell Mol Immunol. 2025 Mar;22(3):282-299. doi: 10.1038/s41423-025-01260-3.

23.  Qian P, Li Y, Han Y, Xu C, Zou P, Yang F, Kang X, Wu M, Dong J, Zou Z, Wei J*.Palmitic acid reprograms neutrophils to compromise vascular integrity and promote breast cancer lung metastasis. mmunity. 2026 Jul 14;59(7):1964-1981.e9. doi: 10.1016/j.immuni.2026.03.026.

24.  Han Y, Qian P, Li Y, Kang X, Zou P, He B, Wei J. A recyclable antibody shield preserves LDL receptor homeostasis and enables durable lipid control without immune complex formation.Pharmacol Res. 2026 Sep;231:108371. doi: 10.1016/j.phrs.2026.108371.

国家自然科学基金项目：

1、脂质代谢重编程驱动中性粒细胞损伤肺血管内皮屏障促进三阴性乳腺癌肺倾向性转移的机制与干预策略，国家自然科学基金面上项目  82573534 在研，主持

2、胆固醇代谢调节肿瘤相关巨噬细胞在神经胶质瘤进展中的作用机制及治疗策略研究，国家自然科学基金面上项目82273261，在研，主持

3、新型核苷酸嵌合体靶向调控免疫耐受微环境治疗实体肿瘤。国家自然科学基金面上项目81773255，结题，主持

4、靶向神经胶质瘤有氧糖酵解的病毒溶瘤策略及机制研究。国家自然科学基金面上项目81472820，结题，主持

5、多功能小干扰RNA：同时沉默VEGF、激活RIG-I信号通路和caspase级联反应治疗非小细胞肺癌。国家自然科学基金面上项目81172143，结题，主持

6、内皮祖细胞介导溶瘤麻疹病毒疫苗株治疗人肺癌：体外最佳装载策略、体内“药代动力学”研究。国家自然科学基金面上项目81071860，结题，主持

其他：

1、基于LDLR特殊表位的新型高长效降脂抗体药物临床前研发，临港国家实验室LGL-2612-04，在研，主持。

2、江苏省科技厅重点研发计划项目（BL2014054），结题，主持。

德国乌尔姆大学优秀博士论文奖（2004）

bv伟德源自英国始于1946优秀博士生导师（2014）

bv伟德源自英国始于1946“我最喜爱的老师”（2018）

bv伟德源自英国始于1946魅力导师（2019）